Sastry, B.S. and Suresh Babu, K. and Hari Babu, T. and Chandrasekhar, S. and Srinivas, P.V. and Saxena, A.K. and Madhusudana Rao, J. (2006) Synthesis and biological activity of amide derivatives of nimbolide. Bioorganic & Medicinal Chemistry Letters, 16 (16). pp. 4391-4394. ISSN 0960894X
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Official URL: http://dx.doi.org/10.1016/j.bmcl.2006.05.105
Abstract
Nimbolide (1), a limonoid isolated from Azadirachta indica, is the chief cytotoxic principle in Neem leaves extract. Using nimbolide as a lead compound for anti-cancer analogue design, a series of nimbolide derivatives have been synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 10 compounds screened 2g, 2h and 2i showed potent activity.
| Item Type: | Article |
|---|---|
| Subjects: | Chemical Sciences Pharmacological Sciences |
| Divisions: | UNSPECIFIED |
| Depositing User: | Mr. Amit Nargotra |
| Date Deposited: | 03 Jan 2012 04:59 |
| Last Modified: | 03 Jan 2012 04:59 |
| URI: | http://iiim.csircentral.net/id/eprint/349 |
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