Mirza, Z. M. and Kumar, A. and Kalia, N. P. and Zargar, A. and Khan, I. A. (2011) Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus. Journal of Medical Microbiology, 60 (10). pp. 1472-1478. ISSN 0022-2615

PDF - Published Version Restricted to Registered users only Download (225Kb) | Request a copy

Abstract

Piperine, a trans-trans-isomer of 1-piperoyl-piperidine, was tested in combination with mupirocin for antimicrobial activity against Staphylococcus aureus strains including meticillin-resistant S. aureus. The combination markedly reduced the MIC of mupirocin and also lowered the mutation frequency. Enhanced accumulation and efflux of ethidium bromide from wild-type and mutant (Mupr-1) strains in the presence of piperine indicated that inhibition of efflux could be a possible mechanism of potentiation of mupirocin activity by piperine. The combination of piperine ; with mupirocin in a dermal infection model of mice showed better in vivo efficacy when compared with the commercially available formulation of 2% mupirocin.

Item Type:	Article
Subjects:	Pharmacological Sciences
Divisions:	UNSPECIFIED
Depositing User:	Mr. Amit Nargotra
Date Deposited:	02 Jan 2012 11:14
Last Modified:	02 Jan 2012 11:14
URI:	http://iiim.csircentral.net/id/eprint/311

Actions (login required)

View Item