Singh, Rajinder and Bhella, Surinderjit Singh and Sexana, A.K. and Shanmugavel, M. and Faruk, Abdul and Ishar, M.P.S. (2007) Investigations of regio- and stereoselectivities in the synthesis of cytotoxic isoxazolidines through 1,3-dipolar cycloadditions of nitrones to dipolarophiles bearing an allylic oxygen. Tetrahedron, 63 (10). pp. 2283-2291. ISSN 00404020

PDF - Published Version Restricted to Registered users only Download (367Kb) | Request a copy

Abstract

Abstract—Regio- and stereoselectivities in cycloadditions of nitrones to dipolarophiles bearing an allylic oxygen, which furnishes substituted-isoxazolidine analogs of the furanose ring of nucleosides, have been investigated. Although the obtained regioselectivities are anticipated, a rationalization of the preferred formation of endo-cycloadducts necessitates the involvement of an allylic oxygen in secondary interaction. The obtained isoxazolidines display cytotoxic activities against a number of human cancer cell lines.

Item Type:	Article
Subjects:	Chemical Sciences
Divisions:	UNSPECIFIED
Depositing User:	Mr. Amit Nargotra
Date Deposited:	28 Dec 2011 11:31
Last Modified:	28 Dec 2011 11:31
URI:	http://iiim.csircentral.net/id/eprint/279

Actions (login required)

View Item