Sondhi, Sham M. and Rani, Reshma and Roy, Partha and Agrawal, S.K. and Saxena, A.K. (2009) Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities. Bioorganic & Medicinal Chemistry Letters, 19 (5). pp. 1534-1538. ISSN 0960894X

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Abstract

A number of N-substituted cyclic imides 3a–e, 5a–e, 7a–d, and 9a–e have been synthesized in very high yields, by condensation of various diacids 2, 4, 6, and 8 with different amines under microwave irradiation.These compounds were screened for anticancer and anti-inflammatory activities, and compounds 3c, 3e, 5c, 9c, and 9d exhibited anticancer activity against colon (COLO 205) cancer better than 5-fluorouracil and mitomycin-C, and compound 9b exhibited anti-inflammatory activity better than standard drug phenyl butazone.

Item Type:	Article
Subjects:	Chemical Sciences Pharmacological Sciences
Divisions:	UNSPECIFIED
Depositing User:	Mr. Amit Nargotra
Date Deposited:	02 Jan 2012 10:45
Last Modified:	02 Jan 2012 10:45
URI:	http://iiim.csircentral.net/id/eprint/291

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