Khan, I. A. and Mirza, Z. M. and Kumar, A. and Verma, V. and Qazi, G. N. (2006) Piperine, a Phytochemical Potentiator of Ciprofloxacin against Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 50 (2). pp. 810-812. ISSN 0066-4804

[img] PDF - Published Version
Restricted to Registered users only

Download (60Kb) | Request a copy


Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced the MICs and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant S. aureus. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial efflux pumps.

Item Type: Article
Subjects: Pharmacological Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 03 Jan 2012 05:40
Last Modified: 03 Jan 2012 05:40

Actions (login required)

View Item View Item