Sondhi, Sham M. and Singh, Jaiveer and Rani, Reshma and Gupta, P.P. and Agrawal, S.K. and Saxena, A.K. (2010) Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives. European Journal of Medicinal Chemistry, 45 (2). pp. 555-563. ISSN 02235234

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Condensation of 9-chloro-2,4-(un)substituted acridines (1a–c) with various amines (2a–e) and 9-isothiocyanato- 2,4-(un)substituted acridines (4a,b) with different amines (2a,b,d,e) gave condensed products 3a–o and 5a–g respectively. Compounds 3a–o and 5a–g were screened for anti-inflammatory activity at a dose of 50 mg/kg p.o. Compound 3e exhibited 41.17% anti-inflammatory activity which is better than most commonly used standard drug ibuprofen which showed 39% anti-inflammatory (at 50 mg/kg p.o.) activity. Anticancer activity evaluation of compounds 3a–o and 5a–g was carried out against a small panel of human cancer cell lines and compounds 3g, 3m and 5g exhibited good anticancer activity against breast (MCF-7), liver (HEP-2), colon (COLO-205, 502713, HCT-15), lung (A-549)and neuroblastoma (IMR-32) cancer cell lines at a concentration of 1� 10�5 M.

Item Type: Article
Subjects: Chemical Sciences
Pharmacological Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 03 Jan 2012 05:21
Last Modified: 03 Jan 2012 05:21

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