Bhattacharya, Asish K. and Rana, Kalpeshkumar C. and Mujahid, Mohammad and Sehar, Irum and Saxena, Ajit K. (2009) Synthesis and in vitro study of 14-aryl-14H-dibenzo[a.j]xanthenes as cytotoxic agents. Bioorganic & Medicinal Chemistry Letters, 19 (19). pp. 5590-5593. ISSN 0960894X

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A simple and expedient method for the synthesis of a series of 14-aryl-14H-dibenzo[a.j]xanthenes is described through a one-pot condensation of b-naphthol with aryl aldehydes catalysed by TaCl5 under solvent-free conventional heating. The major advantages of the present method are: high yields, less reaction time, solvent-free condition and easy purification of the products. The synthesized 14-aryl- 14H-dibenzo[a.j]xanthenes were evaluated against a panel of six human cancer lines of different tissues.Synthesized compound 3o showed IC50 of 37.9 and 41.3 lM against Colo-205 and 502713, respectively,whereas 3g showed IC50 of 41.9 lM against Colo-205.

Item Type: Article
Subjects: Chemical Sciences
Pharmacological Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 03 Jan 2012 05:15
Last Modified: 03 Jan 2012 05:15

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