Ishar, M.P.S. and Raj, Tilak and Agrawal, Satyam Kumar and Saxena, A.K. and Singh, Lakhwinder and Singh, Rajinder and Bhella, Surinderjit Singh (2008) Synthesis and cytotoxic activity of some novel polycyclic γ-butyrolactones. Bioorganic & Medicinal Chemistry Letters, 18 (17). pp. 4809-4812. ISSN 0960894X

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Baeyer–Villiger oxidation of 5-aryl-7,11,11-trimethyltricyclo[,6]-undec-1-en-4-ones 4a–h by H2O2 and formic acid in methanol yields mixtures of 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro- 1H-indeno-[1,2-c]furan-1-ones 8a–h and 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro-1H-indeno-[1,2-c]furan-2-ones 9a–h in high yields. The obtained butyrolactones 8a–h display cytotoxic activity against a number of human cancer cells.

Item Type: Article
Subjects: Chemical Sciences
Pharmacological Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 03 Jan 2012 05:14
Last Modified: 03 Jan 2012 05:14

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