Ishar, M.P.S. and Raj, Tilak and Agrawal, Satyam Kumar and Saxena, A.K. and Singh, Lakhwinder and Singh, Rajinder and Bhella, Surinderjit Singh (2008) Synthesis and cytotoxic activity of some novel polycyclic γ-butyrolactones. Bioorganic & Medicinal Chemistry Letters, 18 (17). pp. 4809-4812. ISSN 0960894X
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Abstract
Baeyer–Villiger oxidation of 5-aryl-7,11,11-trimethyltricyclo[5.4.0.03,6]-undec-1-en-4-ones 4a–h by H2O2 and formic acid in methanol yields mixtures of 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro- 1H-indeno-[1,2-c]furan-1-ones 8a–h and 3b,7,7-trimethyl-3-phenyl-3,3a,3b,4,5,6,7,8a-octahydro-1H-indeno-[1,2-c]furan-2-ones 9a–h in high yields. The obtained butyrolactones 8a–h display cytotoxic activity against a number of human cancer cells.
| Item Type: | Article |
|---|---|
| Subjects: | Chemical Sciences Pharmacological Sciences |
| Divisions: | UNSPECIFIED |
| Depositing User: | Mr. Amit Nargotra |
| Date Deposited: | 03 Jan 2012 05:14 |
| Last Modified: | 03 Jan 2012 05:14 |
| URI: | http://iiim.csircentral.net/id/eprint/353 |
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