Bhat, B.A. and Dhar, K.L. and Puri, S.C. and Saxena, A.K. and Shanmugavel, M. and Qazi, G.N. (2005) Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents. Bioorganic & Medicinal Chemistry Letters, 15 (12). pp. 3177-3180. ISSN 0960894X

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Abstract

A series of substituted chalcones and their corresponding pyrazoles were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 93 compounds screened, 8 compounds, 1s, 3i,j,n, 4i,j,n and 4s, showed marked activity. Compounds 4j,n and 4s were found to be the most promising in this study. SAR is also discussed.

Item Type:	Article
Subjects:	Chemical Sciences Pharmacological Sciences
Divisions:	UNSPECIFIED
Depositing User:	Mr. Amit Nargotra
Date Deposited:	03 Jan 2012 05:00
Last Modified:	03 Jan 2012 05:00
URI:	http://iiim.csircentral.net/id/eprint/350

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