Sastry, B.S. and Suresh Babu, K. and Hari Babu, T. and Chandrasekhar, S. and Srinivas, P.V. and Saxena, A.K. and Madhusudana Rao, J. (2006) Synthesis and biological activity of amide derivatives of nimbolide. Bioorganic & Medicinal Chemistry Letters, 16 (16). pp. 4391-4394. ISSN 0960894X

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Nimbolide (1), a limonoid isolated from Azadirachta indica, is the chief cytotoxic principle in Neem leaves extract. Using nimbolide as a lead compound for anti-cancer analogue design, a series of nimbolide derivatives have been synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 10 compounds screened 2g, 2h and 2i showed potent activity.

Item Type: Article
Subjects: Chemical Sciences
Pharmacological Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 03 Jan 2012 04:59
Last Modified: 03 Jan 2012 04:59

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