Shah, Bhahwal Ali and Kaur, Rajbir and Gupta, Pankaj and Kumar, Ajay and Sethi, Vijay Kumar and Andotra, Samar Singh and Singh, Jaswant and Saxena, Ajit Kumar and Taneja, Subhash Chandra (2009) Structure–activity relationship (SAR) of parthenin analogues with pro-apoptotic activity: Development of novel anti-cancer leads. Bioorganic & Medicinal Chemistry Letters, 19 (15). pp. 4394-4398. ISSN 0960894X

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Analogues of parthenin were synthesized by substitutions at different reaction centres to establish a structure–activity relationship (SAR). Some of the molecules have displayed significant cytotoxicity in human cervical carcinoma (HeLa) and human myeloid leukemia (HL-60) cells. A few of the compounds also induced apoptosis in HL-60 cells measured in terms of sub-Go/G1 DNA fraction. Also one of the lead molecules has been shown to be the inhibitor of both telomerase and topoisomerase-II.

Item Type: Article
Subjects: Chemical Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 03 Jan 2012 04:55
Last Modified: 03 Jan 2012 04:55

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