Bhat, Khurshid A. and Shah, Bhahwal A. and Gupta, Kuldeep K. and Pandey, Anjali and Bani, Sarang and Taneja, Subhash C. (2009) Semi-synthetic analogs of pinitol as potential inhibitors of TNF-α cytokine expression in human neutrophils. Bioorganic & Medicinal Chemistry Letters, 19 (7). pp. 1939-1943. ISSN 0960894X

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Semi-synthetic analogs of pinitol were subjected to screening by determining TNF-a expression in human neutrophils using flowcytometry. Among the tested compounds, three derivatives displayed more than 50% inhibition of TNF-a cytokine secretion in LPS induced stimulated neutrophils and can be considered as potent anti-inflammatory moieties.

Item Type: Article
Subjects: Chemical Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 02 Jan 2012 12:13
Last Modified: 02 Jan 2012 12:13

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