Bhat, Khurshid A. and Shah, Bhahwal A. and Gupta, Kuldeep K. and Pandey, Anjali and Bani, Sarang and Taneja, Subhash C. (2009) Semi-synthetic analogs of pinitol as potential inhibitors of TNF-α cytokine expression in human neutrophils. Bioorganic & Medicinal Chemistry Letters, 19 (7). pp. 1939-1943. ISSN 0960894X
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Official URL: http://dx.doi.org/10.1016/j.bmcl.2009.02.050
Abstract
Semi-synthetic analogs of pinitol were subjected to screening by determining TNF-a expression in human neutrophils using flowcytometry. Among the tested compounds, three derivatives displayed more than 50% inhibition of TNF-a cytokine secretion in LPS induced stimulated neutrophils and can be considered as potent anti-inflammatory moieties.
| Item Type: | Article |
|---|---|
| Subjects: | Chemical Sciences |
| Divisions: | UNSPECIFIED |
| Depositing User: | Mr. Amit Nargotra |
| Date Deposited: | 02 Jan 2012 12:13 |
| Last Modified: | 02 Jan 2012 12:13 |
| URI: | http://iiim.csircentral.net/id/eprint/339 |
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