Shah, Bhahwal Ali and Chib, Renu and Gupta, Pankaj and Sethi, Vijay Kumar and Koul, Surrinder and Andotra, Samar Singh and Nargotra, Amit and Sharma, Sujata and Pandey, Anjali and Bani, Sarang and Purnima, Basant and Taneja, Subhash Chandra (2009) Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus. Organic & Biomolecular Chemistry, 7 (16). p. 3230. ISSN 1477-0520

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Two novel saponins and a 13-nor-pseudoguaianolide designated as hysterolactone were isolated from Parthenium hysterophorus. The two saponins were found to be potent inhibitors of TNF-a. Their mode of inhibition was studied through molecular modeling. The wet lab results were in concordance with the data obtained from docking experiments.

Item Type: Article
Subjects: Chemical Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 02 Jan 2012 12:10
Last Modified: 02 Jan 2012 12:10

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