Yousuf, Syed Khalid and Majeed, Rabiya and Ahmad, Mudassier and Sangwan, Payare lal and Purnima, Basant and Saxsena, A.K. and Suri, K.A. and Mukherjee, Debaraj and Taneja, Subhash Chandra (2011) Ring A structural modified derivatives of withaferin A and the evaluation of their cytotoxic potential. Steroids, 76 (10-11). pp. 1213-1222. ISSN 0039128X

PDF - Published Version Restricted to Registered users only Download (625Kb) | Request a copy

Abstract

Regio-/stereoselective Michael addition to ring A of withaferin-A was performed using an optimized reaction procedure to synthesise a library of 2,3-dihydro,3-�-substituted withaferin-A derivatives. The analogues thus obtained were evaluated for in vitro cytotoxicity against various human cancer cell lines.3-Azido analogue exhibited 35-fold increase (IC50 = 0.02–1.9 �M) in cytotoxicity against almost the entire cell lines tested when compared to the parent molecule. However, further modifications of 3-azido analogue with various alkynes under Husigen’s cycloaddition conditions generated a variety of triazole derivatives with reduced cytotoxicity.

Item Type:	Article
Subjects:	Chemical Sciences
Divisions:	UNSPECIFIED
Depositing User:	Mr. Amit Nargotra
Date Deposited:	02 Jan 2012 12:09
Last Modified:	02 Jan 2012 12:09
URI:	http://iiim.csircentral.net/id/eprint/333

Actions (login required)

View Item