Singh, Parvinder Pal and Qazi, Naveed Ahmed and Shafi, Syed and Reddy, D. Mahendhar and Banday, Abid H. and Reddy, P. Bhaskar and Suri, K.A. and Gupta, B.D. and Satti, N.K. and Wakhloo, Basant P. and Kumar, H.M. Sampath and Qazi, G.N. (2009) Regio-selective acylation of biologically important iridoid glycosides by Candida antarctica lipase. Journal of Molecular Catalysis B: Enzymatic, 56 (1). pp. 46-54. ISSN 13811177

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Lipase catalyzed regio-selective acylation of five iridoid glycosides viz., picroside I&II, catalpol, agnuside and negundoside in the presence of various acyl donors such as vinyl acetate and p-nitrophenyl alkanoates was studied. The regio-selectivity of enzymatic acylation and yieldswere found to vary amongst different substrates. Monoacylated products were isolated with all the substrates under scrutiny indicating high regio-selective nature of such transformations. A series of acyl esters of picroside-I, picroside-II, catalpol, agnuside and negundoside have been synthesized by this enzymatic trans-esterification methodology.

Item Type: Article
Subjects: Chemical Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 02 Jan 2012 12:08
Last Modified: 02 Jan 2012 12:08

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