Sangwan, Payare L. and Koul, Jawahir L. and Koul, Surrinder and Reddy, Mallepally V. and Thota, Niranjan and Khan, Inshad A. and Kumar, Ashwani and Kalia, Nitin P. and Qazi, Ghulam N. (2008) Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors. Bioorganic & Medicinal Chemistry, 16 (22). pp. 9847-9857. ISSN 09680896

[img] PDF - Published Version
Restricted to Registered users only

Download (264Kb) | Request a copy


Based on our recent findings that piperine is a potent Staphylococcus aureus NorA efflux pump inhibitor(EPI), 38 piperine analogs were synthesized and bioevaluated for their EPI activity. Twenty-five of them were found active with potentiating activity equivalent or more than known EPIs like reserpine, carsonic acid and verapamil. The inhibitory mechanism of the compounds was confirmed by efflux inhibition assay using ethidium bromide as NorA substrate. The present communication describes the synthesis,bioevaluation and structure related activity of these efflux pump inhibitors.

Item Type: Article
Subjects: Chemical Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 02 Jan 2012 11:12
Last Modified: 02 Jan 2012 11:12

Actions (login required)

View Item View Item