Najar, I. A. and Sachin, B. S. and Sharma, S. C. and Satti, N. K. and Suri, K. A. and Johri, R. K. (2010) Modulation of P-glycoprotein ATPase activity by some phytoconstituents. Phytotherapy Research, 24 (3). pp. 454-458. ISSN 0951418X

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In the present investigation 16 phytoconstituents, which are active moieties found in several medicinal herbs, have been evaluated for their P-glycoprotein (P-gp) stimulation/inhibition profi les using a P-gp-dependent ATPase assay in rat jejunal membrane (in vitro). Acteoside, agnuside, catechin, chlorogenic acid, picroside -II and santonin showed an inhibitory effect. Negundoside, picroside -I and oleanolic acid caused a stimulatory effect. Andrographolide, apocyanin, berberine,glycyrrhizin, magniferin and piperine produced a biphasic response (stimulation at low concentration and inhibition at high concentration). The results suggested that a possible interaction of these phytoconstituents at the level of P-gp, could be an important parameter in determining their role in several key pharmacodynamic events.

Item Type: Article
Subjects: Chemical Sciences
Pharmacological Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 02 Jan 2012 10:49
Last Modified: 02 Jan 2012 10:49

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