Nazir, Nighat and Koul, Surrinder and Qurishi, Mushtaq A. and Taneja, Sachin C. and Ahmad, Sheikh F. and Bani, Sarang and Qazi, Ghulam N. (2007) Immunomodulatory effect of bergenin and norbergenin against adjuvant-induced arthritis—A flow cytometric study. Journal of Ethnopharmacology, 112 (2). pp. 401-405. ISSN 03788741

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Bergenin (1), a C-glycoside of 4-O-methyl gallic acid, isolated from rhizomes of Bergenia stracheyi (Saxifragaceae) and its O-demethylated derivative norbergenin (2), prepared from 1, are reported to show anti-arthritic activity through possible modulation of Th1/Th2 cytokine balance.Flow cytometric study showed that the oral administration of 1 and 2 at doses of 5, 10, 20, 40 and 80 mg/kg per oral dose inhibit the production of proinflammatory Th1 cytokines (IL-2, IFN-� and TNF-�) while as potentiate anti-inflammatory Th2 cytokines (IL-4 and IL-5) in the peripheral blood of adjuvant-induced arthritic balb/c mice. This shows the potential Th1/Th2 cytokine balancing activity of 1 and 2 which is strongly correlated with their anti-arthritic activity. At similar dose levels, the effect of 2 was found to be more than that of 1. The oral LD0 for 1 and 2 was more than 2000 mg/kg body weight of the mice.

Item Type: Article
Subjects: Pharmacological Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 28 Dec 2011 09:37
Last Modified: 28 Dec 2011 09:37

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