Singh, Shashank Kumar and Bhusari, Sachin and Singh, Reena and Saxena, Ajit and Mondhe, Dilip and Qazi, Ghulam Nabi (2007) Effect of acetyl 11-keto β-boswellic acid on metastatic growth factor responsible for angiogenesis. Vascular Pharmacology, 46 (5). pp. 333-337. ISSN 15371891

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Basic fibroblast growth factor (bFGF), a metastatic growth factor is known to be one of the promoting factors in the tumor induced angiogenesis. The antiangiogenic activity of acetyl 11-keto β-boswellic acid was screened against bFGF-induced angiogenesis using in-vivo Matrigel Plug Assay. Histological & colorimetric examination confirmed that numerous blood vessels were present in Matrigel+bFGF group in comparison to Matrigel alone treated mice. Acetyl 11-keto β-boswellic acids (10 mg/kg/d) inhibited the Matrigel+bFGF-induced angiogenesissignificantly (Pb0.01) in contrast to anti-inflammatory agent indomethacin (10 mg/kg/d) and alkylating agent cyclophosphamide (10 mg/kg/d).

Item Type: Article
Subjects: Pharmacological Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 28 Dec 2011 08:30
Last Modified: 28 Dec 2011 08:30

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