Reddy, Pitta B. and Paul, David V. and Agrawal, Satyam K. and Saxena, Ajit K. and Kumar, Halmuthur M. S. and Qazi, Ghulam N. (2008) Design, Synthesis, and Biological Testing of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxin Analogues as Antitumor Agents. Archiv der Pharmazie, 341 (2). pp. 126-131. ISSN 03656233

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A series of 4b-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin analogues have been synthesized with high regio-selectivity by employing copper(I)-catalyzed 1,3-dipolar cycloaddition of 1-O-propargyl monosaccharides with C4b-azido podophyllotoxin and C4b-azido-49-O-demethyl podophyllotoxin.All the compounds were evaluated for their anticancer activity against a panel of six human cancer cell lines. Among these, 49-O-demethyl podophyllotoxin congeners are showing promising anticancer activity mainly against HCT-15 (colon) and DU-145 (prostate) cells.

Item Type: Article
Subjects: Chemical Sciences
Pharmacological Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 28 Dec 2011 08:26
Last Modified: 28 Dec 2011 08:26

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