Sondhi, Sham M. and Rani, Reshma and Roy, Partha and Agrawal, S.K. and Saxena, A.K. (2010) Conventional and microwave assisted synthesis of small molecule based biologically active heterocyclic amidine derivatives. European Journal of Medicinal Chemistry, 45 (3). pp. 902-908. ISSN 02235234

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Heterocyclic amidine derivatives have been synthesized by condensation of 2-cyanopyrazine, 4-cyanopyridine and 2-cyanopyridine with furfurylamine, histamine, 1-(3-aminopropyl)imidazole, 4-picolylamine, 2-picolylamine, and tryptamine respectively, in the presence of sodium methoxide as well as via microwave irradiation in good yields. All these compounds were screened for anti-inflammatory and anticancer activities. At a dose of 50 mg/kg p.o. compounds 3a (36.6%), 3d (32%), 4d (31.0%) and 4e(33.8%) exhibited good anti-inflammatory activity, comparable to standard drug ibuprofen which showed 39% activity at 50 mg/kg p.o.

Item Type: Article
Subjects: Chemical Sciences
Pharmacological Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 28 Dec 2011 08:24
Last Modified: 28 Dec 2011 08:24

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