Goswami, Abhishek and Saikia, Partha P. and Barua, Nabin C. and Bordoloi, Manobjyoti and Yadav, Archana and Bora, Tarun C. and Gogoi, Binod K. and Saxena, Ajit Kumar and Suri, Nithasa and Sharma, Madhunika (2010) Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimum. Bioorganic & Medicinal Chemistry Letters, 20 (1). pp. 359-361. ISSN 0960894X

[img] PDF - Published Version
Restricted to Registered users only

Download (195Kb) | Request a copy


Potent antimalarial compound artemisinin, 1 was bio-transformed to C-9 acetoxy artemisinin, 2 using soil microbe Penicillium simplissimum along with C-9 hydroxy derivative 3. The products were characterized using high field NMR and MS–MS data. The absolute stereochemistry of the newly generated chiral centers has been ascertained by COSY and 1D NOESY experiments. This is the first Letter of direct C-acetoxylation of artemisinin using microbial strains.

Item Type: Article
Subjects: Pharmacological Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 28 Dec 2011 08:11
Last Modified: 28 Dec 2011 08:11
URI: http://iiim.csircentral.net/id/eprint/223

Actions (login required)

View Item View Item