Anand, Naveen and Kapoor, Munish and Ahmad, Khursheed and Koul, Surrinder and Parshad, Rajinder and Manhas, Kuldip S. and Sharma, Rattan L. and Qazi, Ghulam N. and Taneja, Subhash C. (2007) Arthrobacter sp.: a lipase of choice for the kinetic resolution of racemic arylazetidinone precursors of taxanoid side chains. Tetrahedron: Asymmetry, 18 (9). pp. 1059-1069. ISSN 09574166

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The native strain of Arthrobacter sp. (MTCC 5125) bearing a lipase has been found to be the most effective in the kinetic resolution of racemic arylazetidinones for producing cis-(3R,4S)-3-acetoxy-1-(4-methoxyphenyl)-4-phenyl-2-azetidinone, cis-(3R,4R)-3-acetoxy-1-(4-methoxyphenyl)-4-(2-furanyl)-2-azetidinone, cis-(3R,4R)-3-acetoxy 1-(4-methoxyphenyl)-4-(2-thienyl)-2-azetidinone, and cis-3-acetoxy-4-(t-butyl)-2-azetidinone products. The resolved compounds, which were obtained in high enantiopurity are important intermediates of amino acid side chains of paclitaxel

Item Type: Article
Subjects: Chemical Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 28 Dec 2011 08:10
Last Modified: 28 Dec 2011 08:10

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