Kamal, Ahmed and Shetti, Rajesh V.C.R.N.C. and Azeeza, Shaik and Ahmed, S. Kaleem and Swapna, P. and Reddy, A. Malla and Khan, Inshad Ali and Sharma, Sandeep and Abdullah, Sheikh Tasduq (2010) Anti-tubercular agents. Part 5: Synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners. European Journal of Medicinal Chemistry, 45 (10). pp. 4545-4553. ISSN 02235234

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In an effort to discover new and effective chemotherapeutic agents from this laboratory for the treatment of tuberculosis, here in we describe the synthesis and biological evaluation of a series of novel benzothiadiazine 1,1-dioxide (BTD) based congeners by using rifampicin, streptomycin; ciprofloxacin and amphotericin as positive controls. Further, to understand structural requirements for exploring the structure activity relationship of BTDs, cytotoxicity and in vivo study of recently reported potent molecule 4 (MIC ¼ 1 mg/mL) is also discussed.

Item Type: Article
Subjects: Pharmacological Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 28 Dec 2011 06:24
Last Modified: 28 Dec 2011 06:24
URI: http://iiim.csircentral.net/id/eprint/214

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