Gupta, Pankaj and Taneja, Subhash C. and Shah, Bhahwal A. and Mukherjee, Debaraj and Parshad, Rajinder and Chimni, Swapandeep S. and Qazi, Ghulam N. (2008) An expedient chemo-enzymatic method for the synthesis of optically active masked 1,2-amino alcohols. Tetrahedron: Asymmetry, 19 (16). pp. 1898-1903. ISSN 09574166

[img] PDF - Published Version
Restricted to Registered users only

Download (371Kb) | Request a copy


The expedient synthesis of enantiopure masked 1,2-amino alcohols (ee >99%) including their alkyl substituted analogues has been achieved by the regioselective ring opening of epoxides using phthalimide,followed by highly efficient kinetic resolution under mild and environmentally friendly conditions. The addition of co-solvents during kinetic resolution significantly improved the enantioselectivity with reduction in time.

Item Type: Article
Subjects: Chemical Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 19 Dec 2011 09:39
Last Modified: 19 Dec 2011 09:39

Actions (login required)

View Item View Item