Pandey, Anjali and Kour, Kiranjeet and Bani, Sarang and Suri, Krishna Avtar and Satti, Naresh Kumar and Sharma, Punita and Qazi, Ghulam Nabi (2009) Amelioration of adjuvant induced arthritis by apocynin. Phytotherapy Research, 23 (10). pp. 1462-1468. ISSN 0951418X

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The premise of the study was to investigate the antiarthritic potential of apocynin (APO) in Balb/c mice (in vivo). The experiment showed a dose-dependent decrease in oedema and showed a suppression of proinflammatory cytokines such as TNF-α and IL-1β and mediators such as prostaglandin E2 (PGE2)and LTB4. At oral doses of 0.5, 1.0, 2.0 and 4.0 mg/kg once daily during the course of the experiment,APO induced an inhibition of T cell mediated immune response causing suppression of CD4+ and CD8+ T cells and of intracellular interferon-gamma (IFN-γ ) by flow cytometry in arthritic mice. In parallel there was a dose-dependent inhibition in vascular permeability causing an inhibition in the migration of leucocytes and exudate volume at the site of the inflammatory reaction. These observations validate the immunoregulatory potential of apocynin. Copyright © 2009 John Wiley & Sons, Ltd.

Item Type: Article
Subjects: Pharmacological Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 19 Dec 2011 08:25
Last Modified: 19 Dec 2011 08:25

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