Singh, B. and Saxena, A. K. and Chandan, B. K. and Gupta, D. K. and Bhutani, K. K. and Anand, K. K. (2001) Adaptogenic activity of a novel, withanolide-free aqueous fraction from the roots ofWithania somnifera Dun. Phytotherapy Research, 15 (4). pp. 311-318. ISSN 0951-418X

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The practitioners of the traditional Indian system of medicine regard Withania somnifera Dun. as the ‘Indian ginseng’. A new withanolide-free aqueous fraction was isolated from the roots of this plant and was evaluated for putative antistress activity against a battery of tests such as hypoxia time, antifatigue effect, swimming performance time, swimming induced gastric ulceration and hypothermia, immobilization induced gastric ulceration, autoanalgesia and biochemical changes in the adrenal glands. This bioactive fraction exhibited significant antistress activity in a dose-related manner in all the parameters studied. The extract of Withania somnifera root (a commercial preparation available locally) was used to compare the results. A preliminary acute toxicity study in mice showed a good margin of safety. Copyright � 2001 John Wiley & Sons, Ltd.

Item Type: Article
Subjects: Pharmacological Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 19 Dec 2011 08:21
Last Modified: 19 Dec 2011 08:21

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