Sharma, Punita and Chauhan, Prashant S. and Dutt, Prabhu and Amina, Musarat and Suri, Krishan A. and Gupta, Bishan D. and Suri, Om P. and Dhar, Kanaya L. and Sharma, Deepak and Gupta, Vivek and Satti, Naresh K. (2011) A unique immuno-stimulant steroidal sapogenin acid from the roots of Asparagus racemosus. Steroids, 76 (4). pp. 358-364. ISSN 0039128X

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Abstract

A new steroidal sapogenin molecule 1 having unique characteristics, 21-nor and unusual C19 carboxylic acid has been isolated from the roots of Asparagus racemosus. On the basis of chemical evidence, extensive spectroscopic analysis including two dimensional (2D) NMR and X-ray studies of single crystal,the structure of 1 was determined as(1S,2R,3S,8S,9S,10S,13S,14S,16S,17R,22R,25R)-21-nor-18�,27�- dimethyl-1�,2�,3�-trihydroxy-25-spirost-4-en-19�-oic acid. 1 crystallizes in monoclinic space group P21 with a = 9.295(2), b = 11.238(2), c = 11.376(2)A˚ ; ˇ = 91.993(4)◦, Z = 2, Dcal = 1.344Mg/m3. The structure was solved by direct methods and refined by full-matrix least-squares procedure to a final R-value of 0.0561 for 4064 observed reflections. 1 was tested against the type of immune responses generated during treatment in normal and immune-suppressed animals and detailed biological activity evaluation suggests it to be a potent immunostimulator.

Item Type:	Article
Subjects:	Chemical Sciences
Divisions:	UNSPECIFIED
Depositing User:	Mr. Amit Nargotra
Date Deposited:	19 Dec 2011 08:19
Last Modified:	19 Dec 2011 08:19
URI:	http://iiim.csircentral.net/id/eprint/199

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