Kaur, Rajbir and Khan, Sheema and Chib, Renu and Kaur, Tandeep and Sharma, Parduman Raj and Singh, Jaswant and Shah, Bhahwal Ali and Taneja, Subhash Chandra (2011) A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid. European Journal of Medicinal Chemistry, 46 (4). pp. 1356-1366. ISSN 02235234

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Abstract

Semi-synthetic analogues of b-boswellic acid (BA) and 11-keto-b-boswellic acid (KBA) were comparatively evaluated for in vitro cytotoxicity against human myeloid leukaemia (HL-60) and human cervical carcinoma (HeLa) cells. 2-Cyano analogues of both the triterpenes were observed to have significant cytotoxicity against both the cells, displaying cytotoxicity in HL-60 cells at low concentrations. Further investigations suggested the proapoptotic potential associated with the two molecules to induce cytotoxicity in HL-60 cells, where one of them showed early proapoptotic effect as evidenced by several biological end-points of the apoptosis such as annexinV binding, DNA fragmentation and increase in sub-G0 DNA fraction and apoptotic bodies formation (Hoechst 33258 staining and SEM studies).

Item Type:	Article
Subjects:	Chemical Sciences Pharmacological Sciences
Divisions:	UNSPECIFIED
Depositing User:	Mr. Amit Nargotra
Date Deposited:	19 Dec 2011 07:20
Last Modified:	19 Dec 2011 07:20
URI:	http://iiim.csircentral.net/id/eprint/184

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