Ali, F. and Sangwan, P. L. and Koul, S. and Pandey, A. and Bani, S. and Abdullah, S. T. and Sharma, P. R. and Kitchlu, S. and Khan, I. A. (2011) 4-epi-Pimaric acid: a phytomolecule as a potent antibacterial and anti-biofilm agent for oral cavity pathogens. European Journal of Clinical Microbiology & Infectious Diseases. ISSN 0934-9723

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The present study focused on the antibacterial and biofilm inhibitory potential of 4-epi-pimaric acid isolated from aerial parts (stem and leaves) of Aralia cachemirica L. (Araliaceae) against oral cavity pathogens. 4-epi-Pimaric acid exhibited minimum inhibitory concentration (MIC) in the range of 4–16 μg/ml and minimum bactericidal concentration (MBC) two- to four-folds higher than MIC. There was significant inhibition in the biofilm formation by Streptococcus mutans on the saliva coated surface (P<0.05), and confocal microscopy revealed that 4-epi-pimaric acid inhibited the clumping and attachment of S. mutans. At 8×MIC concentration, it significantly prevented the pH drop and reduced S. mutans biofilms (P<0.05). Increased propidium iodide staining and leakage of 260- and 280-nm absorbing material by 4-epi-pimaric

Item Type: Article
Subjects: Pharmacological Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 19 Dec 2011 07:06
Last Modified: 19 Dec 2011 07:06

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