Singh, B. and Saxena, A. K. and Chandan, B. K. and Bhardwaj, V. and Gupta, V. N. and Suri, O. P. and Handa, S. S. (2001) Hepatoprotective activity of indigtone-a bioactive fraction fromIndigofera tinctoria Linn. Phytotherapy Research, 15 (4). pp. 294-297. ISSN 0951-418X

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A bioactive fraction, indigtone (FA), obtained by fractionation of a petroleum ether extract of the aerial parts of Indigofera tinctoria, showed significant dose related hepatoprotective activity against CCl4 induced liver injury in rats and mice. Hexobarbitone induced ‘sleeptime’, zoxazolamine induced ‘paralysis time’, levels of transaminases, bilirubin and total protein in serum were employed as indices of liver injury. Pre and post treatment with FA significantly reversed the majority of the parameters altered by the hepatotoxin. This indicated the preventive and restorative effect of FA in the process of CCl4 induced liver damage. The fraction possessed a high therapeutic ratio, as no mortality was observed up to a dose of 2g/kg p.o. in mice

Item Type: Article
Subjects: Chemical Sciences
Depositing User: Mr. Amit Nargotra
Date Deposited: 19 Dec 2011 07:03
Last Modified: 19 Dec 2011 07:03

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